THRIVE

Pan Mass Challenge 2018 - Paul's Posse Rides Again!

On August 5th,  We will suit up for the Pan Mass Challenge, 

Over the past 10 years, we've raised over $2.2 million to fight orphan cancers. Fellow Posse member  Dr. George Demetri's research team at Dana-Farber receives 100% percent of the monies Paul's Posse collects.

This year we are riding for fellow Posse member John Shanahan who recently passed away from a massive heart attack. He was a dear friend of over 20 years who Paul met on his 1st PMC.

He was riding his bike in Sicily on June 9, 2018 on a trip to celebrate a 60th birthday of a fellow Posse member, when he suddenly experienced a life-ending heart attack on the road to Ragusa.

Leading up to the event there was no warning. He was in his usual wonderful spirits right up to the end. He had enjoyed a late lunch in Modica where he was laughing and telling stories. John delighted in being on a bike with his friends. While he left us far too early at the age of 58, we take some consolation that; he was having the time of his life up to the very end.

The hole in the Posse created by his absence serves as a reminder to hug our loved ones a little tighter, for every day is precious.

In addition to your financial support, we would like to ask one more favor. Please solicit a donation from just one other friend or family member. Just think of how much more we can accomplish in our effort to rid our lives of this horrible disease if we broaden our network of giving.

Your tax-deductible check can be made payable to PMC/Jimmy Fund and you can mail it to me. Alternatively, you can use your credit card to make a donation on line http://www2.pmc.org/profile/PS0036

Thank you for your support that allows the Posse to keep working towards conquering this killer, but we can't give up.

Thrive on,

Paul's Posse

Here is a link to a video for your viewing pleasure. http://www.youtube.com/watch?v=ZS50m7w8F-E. It was created by Posse friend and videographer, Sharon Sullivan, who wanted to tell Paul's story of Thriving. We think it captures beautifully what the PMC, and Paul's Posse, are all about. Watching it reminds us of how fortunate we are! (Please feel free to pass on this letter so someone else can see the video)

www.paulsposse.com

http://thriveblog.typepad.com/thrive/

Links

WSJ - Cancer Thriver

Thrive - Paul's Blog

Paul Posse

Paris Brest - Fast Company Profile (Follow up)

Paris Brest - Fast Company Profile

PMC Thrive video

Pan Mass Challenge 2018 - I'm back on the bike!

Already it's June 1st, and another year has passed.   I'm pleased to report that I am still on the bike and again leading the charge at the head of Paul's Posse in the Pan Mass Challenge (PMC) to defeat cancer.

In 8 weeks I will pedal forward for what will be my 21st PMC. It continues to be a privilege to contribute and inspire others to embrace this life saving cause. I consider Paul's Posse to be some of the most important work of my life. It supports vital cures and works for you, for me, for our children and for others battling cancer today and tomorrow. With your generosity, Paul's Posse has raised over $2 million to fight orphan cancers like mine. Fellow Posse member and friend Doctor George Dimitri's research team at Dana-Farber receives 100% of the fully tax-deductible contributions enabled through Paul's Posse.

While I will continue to ride as hard as I can, I am always reminded that whether I succeed or not, this important work must go forward.   Together, we are chipping away and defeating a killer that affects us all.

In addition to your financial support, I'd like to ask one more favor. Please solicit a donation from just one other friend, co-worker, or family member. Just think of how much more we can accomplish in our effort to rid our lives of this horrible disease if we broaden our network of giving.

Your tax-deductible check can be made payable to PMC/Jimmy Fund and you can mail it to me. Alternatively, you can use your credit card to make a donation on line http://www2.pmc.org/profile/PS0036.

If you have questions please do not hesitate to call me at (212) 687-3123 or e-mail [email protected]

Thrive on,

Paul

2017 PMC FINISH!!!

Pan Mass Challenge 2017 - Mission Accomplished!

I have good news and Great news.

The good news is that with Gretchen by my side, I completed my 20th 192-mile Pan Mass Challenge (PMC). It was beyond exhilarating to cross the finish line again, after being sidelined last year.  

I must admit, this year was no easy feat.  The first day was full of flash rainstorms, and the second day had brutal Cape Cod 25mph headwinds coming into Provincetown.

Now, the Great news... "Paul's Posse" has raised more than $70,000 (still very early) this year, raising the Posse's historical total to more than $2million. Unbelievable! 100% of the money goes to the the Dana Farber research team of Dr. George Demetri, my friend and fellow Posse Member, who specializes in orphan cancers like mine. In addition to George riding, we were joined by Dana-Farber physician Andy Wagner.

It has been an emotional journey for the past 10 years. As such, I want to share something that stopped me dead in my tracks (not an easy task, as you know!). Below, I've pasted a letter from my doctor, George Demetri, to members of Paul's Posse.

I encourage you to take a minute to read the letter, because while my words and George's -- by his own admission -- fail to capture the enormity of the support and generosity, his sentiments echo mine. What Paul's Posse has done for George is a reflection of love and friendship that I'm enormously grateful for, and which has pulled me through some very difficult times.

I Thrive on!

Paul

Dear Paul and Members of Paul’s Posse,

Words are completely inadequate to express my heartfelt thanks to everyone for the extraordinary support of our mission here at Dana-Farber Cancer Institute given by all the members of Paul’s Posse through the Pan Mass Challenge.  Since joining together with a shared vision only 10 years ago, this team has raised more than $2 million for research to advance our understanding of GIST so that we can use this knowledge to develop new targeted therapies to help patients.

At the deepest level, this is a testimony to the warmth and respect that we all feel for Paul, and our research team and I are inspired to work harder every day to make the very best use of these important funds.  In these challenging economic times, we make sure that every dollar for research goes as far as it can towards finding new breakthroughs and offering  patients effective new treatment options as quickly as possible, as if our own lives depend on this (since other lives do depend on this).  We are so happy to tell you that these funds are enabling our team to make some of the most rapid translations of laboratory discoveries into clinical application.  In collaboration with colleagues across the world, our team has been privileged to be at the cutting edge of some of the most innovative new drug development projects in GIST and other cancers. 

We simply could never accomplish all that we do in our research without the "grass roots” support of Paul’s Posse, the PMC, and the generosity of all the individual donors who have made this possible.  The Posse has a remarkable spirit, and that spirit has been transformed into the support that powers our research and care mission here at Dana-Farber, and one in which we are working in collaboration with experts around the world to reduce the burden of GIST and other cancers for patients everywhere.

I hope we can all celebrate together again next year, and I certainly hope to share with everyone more results from our very promising work in this field.

POSSE UP, and thanks again to everyone for keeping the spirit thriving!

George D. Demetri, MD

Pan Mass Challenge 2016 - Thrive On!

For 18 years it is been my privilege to ride in the Pan Mass Challenge (PMC) raising much-needed funds to battle cancers that have touched so many of us.  For every one of those years the support of donors, has been the strength and inspiration needed to both help me complete the challenge and to make meaningful contributions to our war on Cancer. I would not have traded a second of that demanding work for anything in the world. I am forever in debt to all for the generous and truly noble financial support.   Donors have been the lifeblood, the strength, and the muscle for everything we have accomplished for Dana-Farber.   Thank you.

Collectively, Paul's Posse has contributed over $2M for the funding of Cancer research in the quest to defeat this disease that has touched every one of us so deeply.

It is with immense sadness and disappointment to tell you that I was unable to ride the PMC this year.  I underwent urgently needed reconstructive surgery on my lower spine.   I am doing very well and am convalescing at home. However, being on the bike is simply beyond me at this time.

Rest assured I'm planning on rejoining the Posse next year.

I THRIVE ON,

Paul

Pan Mass Challenge 2015 - I'm back on the bike!

It is already it's July 1^st , and another year has passed.  I'm pleased to report that I am still on the bike and again leading a charge at the head of Paul's Posse in the Pan Mass Challenge  (PMC) to defeat cancer. 

In four weeks I will pedal forward for what will be my 18th PMC.  It continues to be a privilege to contribute and inspire others to contribute to this life saving cause.  I consider Paul's Posse to be some of the most important work of my life.  It supports vital cures and works for you, for me, for our children and for others battling cancer today and tomorrow.  With your generosity, Paul's Posse has raised over $1.2 million to fight orphan cancers like mine.  Fellow Posse member and friend Doctor George Dimitri's research team at Dana-Farber receives 100% of the fully tax-deductible contributions enabled throughPaul's Posse.

While I will continue to ride as hard as I can, I am always reminded that whether I succeed or not, this important work must go forward.  Together, we are chipping away and defeating a killer that affects us all. 

In addition to your financial support, I'd like to ask one more favor. Please solicit a donation from just one other friend or family member. Just think of how much more we can accomplish in our effort to rid our lives of this horrible disease if we broaden our network of giving. 

Your tax-deductible check can be made payable to PMC/Jimmy Fund and you can mail it to me. Alternatively, you can use your credit card to make a donation on line http://www2.pmc.org/profile/PS0036

Thrive on,

Paul

PMC - Mission FULLY accomplished!

I have good news.....And great news.

The good news is that with Gretchen by my side, I completed my 17th 192-mile Pan Mass Challenge (PMC). After being off the bike, but a loud cheerleader, during last year’s PMC, it was beyond exhilarating to cross the finish line again. Considering that this year’s ride was the "coldest sustained rain" in the ride’s 35-year history, and our longest training ride was only 47 miles, it was an epic journey.

Now, the great news. ...

With your support, Paul's Posse has raised more than $100,000 (still very early) this year, raising the Posse's historical total to more than $1.9 million. Unbelievable! As a reminder, 100% of the money goes to Dr. George Demetri, my friend and fellow Posse Member, who specializes in orphan cancers like mine. In addition to George riding, we were joined by his daughter, Leah (who just got into Harvard Med), and fellow Dana-Farber physician Andy Wagner.

Thank you again for your prior support -- and generosity -- for an event that means more and more to me every year. The thrill of getting on the bike was matched only by my gratitude.

Thrive On,

 

Paul

Pan Mass Challenge 2014 - I'm back on the bike!

I'm back on the bike!

On August 2nd, I will suit up for my 17th Pan Mass Challenge, and ride with Paul's Posse. I can't tell you how thrilled I am to type those words.

I consider the Posse the most important work of my life, because it supports life-saving work. Through your generosity over the years, we've raised $1.2million to fight orphan cancers like mine. Fellow Posse member and friend Dr. George Demetri's research team at Dana-Farber receives 100% percent of the monies Paul's Posse collects.

While I'll be on the bike, I won't be able to complete the full day's ride. For me, that's simply a reminder that this work must go on. Together, we're chipping away at defeating a horrible enemy. But we need to keep doing what we can in order to save lives -- mine, yours, or someone we love.

 In addition to your financial support, I'd like to ask one more favor. Please solicit a donation from just one other friend or family member, and insure that if your employer has a matching program, that they too participate in this worthy work. Just think of how much more we can accomplish in our effort to rid our lives of this horrible disease if we broaden our network of giving.

Your tax-deductible check can be made payable to PMC/Jimmy Fund and you can mail it to me. Alternatively, you can use your credit card to make a donation on line http://www2.pmc.org/profile/PS0036

Thank you for what you have already done. Your support that allows me to keep working towards conquering this killer, but we can't give up.

Thrive on,

Paul

Mission Accomplished! - I have good news. And Great News

The good news is that I completed the 192 mile Pan Mass Challenge.  It wasn't a race, but it wasn't just any ride, either. After being off the bike for 2 years, it was beyond exhilarating to cross the finish line.

Now, the Great News. 

With my friend’s support, Paul's Posse has raised in excess of $210,000 this year, bringing the Posse's cumulative total over the past six years to more than $1.8 million. REMARKABLE!  As a reminder, 100% of the monies we raise go to fund research under the direction of my friend and GIST-focused physician Dr. George Demetri, who specializes in orphan cancers like mine at Dana-Farber. George, his daughter Leah, and others from the Dana-Farber GIST and Sarcoma Center once again rode with us; in addition, we were fortunate to have Dr. Gary Schwartz, Chief of the Sarcoma and Melanoma Service at Memorial Sloan Kettering, and his wife "posse up" and ride with Paul’s Posse this year. Sharing the road revealed another thing they have in common: a deep unwavering commitment to fighting and curing cancer. They are both excited to collaborate and strengthen the bond formed at the PMC.

The funds raised from Paul’s Posse have enabled George’s team at Dana-Farber to pioneer completely new ways of studying GIST. They are developing new laboratory models which are helping to explain why cancers such as GIST develop resistance to Gleevec or other "targeted therapy."  Most exciting, the Dana-Farber team has been
able to leverage this knowledge into a groundbreaking new example of how  effectively academic researchers can collaborate with industry to accelerate new drug development for GIST. On the basis of this work with Bayer Oncology, Dana-Farber investigators have completed worldwide clinical testing of a new "targeted therapy" pill called Regorafenib to combat GIST (my specific cancer); this work was submitted to the FDA at the end of August 2012 for their review, which could hopefully bring a third approved drug for my GIST if one becomes resistant to the two approved drugs, Gleevec and Sutent. 

I am thankful for my friends support -- and generosity --for an event that means  more and more to me every year. The thrill of getting on the bike and finishing is matched only by my gratitude. 

Thrive On,

Paul

Pan Mass Challenge 2012 - Paul Rides Again!

I'm back and with an attitude!

………a totally positive and energized attitude to conquer cancer –  one of the biggest killers in America!

After spending two grumpy years on the sidelines with post-surgery complications, I'm thrilled to tell you I'll be on the bike again this August for the 2 day, 192 mile Pan Mass Challenge. The layoff has meant grueling training -- muscle memory is a myth when it comes to the PMC. Luckily, I’m riding with a world-class medical support team (most people just have a mechanical team; I've got physicians!). Not only is my good friend and doctor from Dana-Farber, George Demetri again riding this year, but also joining me is my friend and physician at Memorial Sloan Kettering, Gary Schwartz and his wife Connie (also a physician).

I will train; I will ride; I will finish; and I will Thrive.

Please join me in leaving nothing to chance, both on the PMC and more importantly, in the fight against cancer.

I'm sure you too want to know where your hard-earned philanthropic dollars are going. Here it is: 100% of the money Paul's Posse raises goes to George at Dana-Farber, to continue his life-saving vital work on orphan cancers, such as mine. If you want proof of impact, look no further than me. George was key to the drug developments combating my cancer. He did not simply change my life, he and others like him, saved it!

It's impossible to overstate how important this life-saving work is to me. I deeply believe in the mission of these doctors an researchers and am asking you to join me in furthering their work. It saved my life…it might save yours or a loved ones, next. This work must continue.

Paul, In addition to your financial support, I'd like to ask a personal favor. It would be wonderful if you would solicit a donation from just one other friend or family member, and insure that if your
employer has a matching program, that they too participate in this worthy work. Just think of how much more we can accomplish in our effort to rid our lives of this horrible disease if we broaden our network of giving.

Your tax-deductible check can be made payable to PMC/Jimmy Fund and you can mail it to me. Alternatively, you can use your  redit card to make a donation on line  ww.pmc.org/mypmc/profiles.asp?Section=story&eGiftID=PS0036 . If you have questions please do not hesitate to call me at (212) 687-3123 or e-mail [email protected].

Thank you for what you have already done. Not a day passes that I don’t recognize that it has been your support that allows me to keep working towards conquering this killer, but I still need your help.

Thrive on,

Paul

Here is a link to a video that was created by Gary Schwartz’s daughter Katherine, who is a sophomore at Wellesley College. She wanted to tell my story of Thriving. I think it captures beautifully what the PMC and Paul's Posse are all about. Watching it reminds me of how fortunate I am! Please share this note, so others can see the video.

 

Cycle for Survival 2012

I have good news and great news.

The good news is that I had a CT scan last Saturday and I am delighted to tell that there's no evidence of disease. My friend, doctor and fellow Posse member Gary Schwartz is so confident that Gleevec is doing its job, he's recommending that I only need to be scanned every 6 months. Amazing!

The great news is that this past weekend Cycle for Survival was held. I am thrilled to report that our team raised more than $35,000. This year's event is on target to raise in excess of $8 million -- 100% of which will go to research for so-called orphan cancers.

I would like to share a video that Gary's daughter Katherine put together for last year's event because I think it captures the essence of Cycle. Each time I watch, it still chokes me up.

I Thrive on,

Paul

If the above link does not work:

http://www.youtube.com/watch?v=o3m8Vsj_E2I

Thrive On - PMC 2011

Thriving takes many forms.

I was reminded of that recently when I participated in my 14th Pan-Mass Challenge, the annual ride across my home state -- and the birthplace of Paul's Posse.

For the second year running, I was on the sidelines instead of on a bike, which I must admit was bittersweet. Watching people ride by carries its own inspiration, but I'm eager to get back on the proverbial horse! My health is improving and I'm disease free. My body continues to defy the odds, and is still responding to Gleevec. PMC 2012, here I come...

I'm especially proud that the Posse rolls on without me...It was 21 riders strong this year, and multi-generational. There were two father/son combos, and the daughter of my doctor, George Demetri, rode along with her dad. That's what Paul's Posse is all about!

George's research into rare cancers again was the beneficiary of the Posse's amazing success -- this year's effort brought the five-year total to more than $1.3 million. Overall, the PMC expects to raise more than $34 million this year in a Posse accident-free event that drew the likes of Lance Armstrong.

I have attached a link to a video for your viewing pleasure. http://www.youtube.com/watch?v=ZS50m7w8F-E. It was created by my friend and videographer, Sharon Sullivan, who wanted to tell my story of Thriving. I think it captures beautifully what the PMC, and Paul's Posse, are all about. Watching it reminds me of how fortunate I am to have friends like you.

This time next year, I'll be posting about my experience RIDING in the Pan-Mass Challenge.

I Thrive On,

Paul

Paul Posse Rode Again! - Cycle for Survival

 Cycle for Survival was held about two weeks ago and I have good news and great news. First the good news: As you may recall, my plan was to be an enthusiastic cheerleader. However, plans change, and due to the cajoling of my fellow posse members... I got on the bike and rode. It was hard, as it is been close to two years that I have done any significant exercise. 

It felt great to get my legs moving again! My plan is to continue to train -- I renewed my gym membership this week -- with the goal of riding the Pan-Mass this summer. This feels wildly ambitious at this point (the Pan-Mass is 192 miles), as I can barely contemplate riding one loop of Central Park, only 6.2 miles. 

Now, the great news. The event raised in excess of $4.5 million, with Paul's Posse raising in excess of $43,000. The importance of all that money was made crystal clear the night of the event. Over a well-earned dinner, my friend and doctor Dr. Gary Schwartz explained how he's continuing to put the Cycle for Survival money to work in his research. In just a few years, Cycle for Survival has funded a total of thirteen clinical trials and studies.

 Thank you again for your love, support -- for this event that means more and more to me every year. The exhilaration of getting on the bike that morning was matched only by my gratitude.

 Thrive On,

Paul

‘Cycle-For-Survival’

I hope all is well and 2011 is off to a great start. 

For the past four years, I have participated in ‘Cycle-For-Survival’, a Memorial Sloan Kettering Cancer Center fundraiser.  It's an indoor cycling event where 100% of every dollar raised will benefit life-saving treatment research for orphan cancers like mine.  Less common but equally dangerous, these cancers do not attract anywhere near the research funding and, therefore, cures are even more elusive. 

Since being diagnosed with cancer in 2006 it has been a journey, albeit one with a great many bumps along the road.  All things considered, I am still very lucky.  Over these past few years, I have met other cancer “Thrivers”. We all share an incredible sense of hope and optimism that one day this horrible disease will be eradicated and that the pain, anguish, and suffering for patients and their loved ones will cease.  

I am taking this challenge seriously, and I can tell you that now more than ever I want to be a part of the effort to search for a solution.  Before my diagnosis, I was actively raising money for cancer research, but in reality, cancer was a concept, a ‘bad’ thing that was happening to ‘other people’.  Today, I am a patient.  Today, I know other patients and we understand the importance of cancer in an all-too intimate way. I cherish every conversation about tomorrow, and I know you all agree that the best tomorrow will be one that's cancer free. 

Thrive On, 

Paul 

Donation Link

http://mskcc.convio.net/site/TR/CycleforSurvival/AG_Cycle_Event?px=1156161&pg=personal&fr_id=1423

Also, check out the video my friend Sharon compiled of Paul's Posse and the Pan-Mass Challenge. 

http://youtu.be/ZS50m7w8F-E

PMC - Paul's Posse Rides Again

Howdy
 
Well, it's that time of year again: the Pan-Mass Challenge is upon us! 
 
As most of you know, I've ridden in this amazing event for the past 12 years. It's a two-day, 192-mile cycling event that raises money to support the Jimmy Fund and the Dana-Farber Cancer Institute. Last year, the PMC raised $31million to fight cancer.

 

Paul's Posse has been a proud and dedicated supporter of the cause. Our 2009 total was $231,768, an amazing number in the depths of a tough economic time. All of that money -- 100% -- went to support the incredible work of my friend and physician, Dr. George D. Demetri at Dana-Farber.

 

I am sorry to report that my body may conspire against me this year. The aftermath of my latest surgery may put me on the sidelines as a reluctant -- but VERY ENTHUSIASTIC -- cheerleader. 

I didn't pick this fight with cancer, but I remain ferocious. Enduring three major abdominal surgeries has only made me stronger and more determined to take each month, week and day as a gift.  

This latest turn of events makes me all the more motivated to once again ask for your generosity for this very worthy cause. Please do whatever you can.

 

I have attached a link to a video for your viewing pleasure. ThriveOn.mov. My friend Sharon Sullivan produced this video to share my story of Thriving and encourage everyone to support this important cause.  I think it captures beautifully what the PMC, and Paul's Posse, are all about. Watching it reminds me of how fortunate I am to have friends like you! (Please feel free to pass on a link to this blog so someone else can see the video)

 

You can use your credit card to make a donation on line http://www.pmc.org/mypmc/profiles.asp?Section=story&eGiftID=PS0036  .
 
I thrive on,

Paul

Good News - I Thrive On!

Howdy,
 
The last time you heard from me, I had good news and bad news. This time, I'm happy to say, it's all good news. I'm back at home after almost two weeks in the hospital recovering from my latest surgery. I'm working hard to get back to work -- and back on my bike.
 
As my doctors had hoped, there was no cancer to be found and believe me, they looked in every nook and cranny. My doctor, Ron DeMatteo, who certainly knows my innards better than anyone at this point, is cautiously optimistic that he has solved the pain issue that has plagued me for the better part of this past year.
 
I cannot overstate my appreciation and affection for the amazing people at Memorial Sloan Kettering. From the doctor who insisted on checking on me coming off a 26-hour shift to the nurse's aide who told me I was like family (three surgeries will do that), it was an amazing experience. It is not just the level of care, but the level of CARING, that blew me away.
 
I feel so grateful for all they did -- and for your support through all of this.
 
I thrive on!

 

Paul

 

 

 

Good News, Bad News - I Thrive On!!!!

Howdy,

 

I wanted to bring you up to date on the latest in my medical adventures. It's a story of good news and bad news.

 

Bad news: I'm going under the knife again, on March 16.

Good news: It's not because the cancer is back. (And that's SERIOUSLY good news).

 

Bad news: They're still not quite sure what's causing my ongoing abdominal pain.

Good news: My doctor told me I have ``the veins of an 18-year-old Navy SEAL.''

 

As all of you know, I'm a good news guy, and that's what I'm completely focused on. I'm confident that this will be what it takes to get me back on the bike, to put that SEAL-like constitution to the test in a race instead of an operating room!

 

Thanks, as always, for your support.

 

I thrive on,

 

Paul

Cycle For Survival - Thank you!!!!

 

 

Howdy,

 

I wanted to give you an update on the extraordinarily successful Cycling for Survival event on Jan 31st. 'Paul's Posse' once again humbled me with its amazing support -- Thanks to many, we contributed over $30,000 to the cause of researching orphan cancers like mine at Memorial Sloan Kettering.

It was, of course, quite a scene, with hundreds of folks pedaling, yelling, and the warmth of all was a stark contrast to the frigid January day. All told, the event raised over $2.2 million.

Among the cyclists were two of my incredible doctors, Dr. Gary Schwartz and Dr. Ronald Dematteo. Unfortunately, I was forced into the role of cheerleader, sidelined by abdominal pain that has become my newest foe. I am currently on a mission to eradicate this situation so I can get back on the bike.  I'm set to undergo further testing this week and my doctors are confident they will solve the issue.  

Thank you again from the bottom of my heart for your generosity to the Cycle for Survival. Being a spectator only deepened my gratitude to the participants and to folks like you who made their hard work worthwhile.

I thrive on,

Paul

Happy New Year - Paul's Posse Rides Again!

Howdy,

One of the greatest joys in my life these days is finding ways to thank the people who are helping to save my life.  Though I continue to thank my doctor and friend Gary Schwartz, there are few better ways to show my profound appreciation than to raise money for cancer research at Memorial Sloan Kettering ("MSK").

For the second year, I'll be joining Gary here in New York for ‘Cycle for Survival’. On January 31, Gary, myself and a couple hundred other maniacs, including another friend and MSK surgeon, Ron DeMatteo, will get on stationary bikes at Equinox Fitness and pedal for 8 hours.

‘Cycle for Survival’ was created in 2007 to raise money to research rare cancers -- like the one that Gary is helping me conquer.  Being less common and equally as dangerous, orphan cancers do not attract the research funding, drug development incentives necessary to promote and advance treatments and, hopefully, cures.  In the last two years more than $ 2 million has been raised for this research.  We hope to continue the success of the event with this year's ambitious but seriously important fund-raising goal of $2 million for research that saves lives. I'm proof.

2009 was a stark reminder that the fight for me goes on, underscoring how important Gary's work is. Less than a year ago, I went through a second round of major abdominal surgery -- a risky procedure that's left me with minor pain and deepening gratitude. Part of my strive to thrive is doing this ride, and getting on a real bike. Paul's Posse is riding again!

I know the holidays are just days behind us, and I realize the economic environment is less than optimal for most of us.  That said, I would be so grateful and appreciative if you would consider making a contribution to this event. Every dollar counts, every dollar makes a difference, and every dollar yields ever increasing possibility.

Click HERE to visit my personal page to make an online donation or you can send a check to my office address below.

Thrive on,

Paul

"Thanks for Giving"

Howdy,

As we look forward to gathering with friends and family next week, I wanted to send along a special note to Paul's Posse saying ``Thanks for Giving!''

 

All of you appreciate the emotions of the journey I've been on during the past three years, but I wanted to share something that stopped me in my tracks (not an easy task, as you know!). Below, I've pasted a letter from my doctor, George Demetri, to all of you. Together, our team has contributed more than ONE MILLION DOLLARS to fund George's research related to GIST and other cancers.

 

I encourage you to take a minute to read the letter, because while my words and George's -- by his own admission -- fail to capture the enormity of your generosity, his sentiments echo mine. What Paul's Posse has done for George is a reflection of love and friendship that I'm enormously grateful for, and which has pulled me through some very difficult times.

 

Please know that I'll be giving thanks for all of you next week, and always. Be well, and as always...

Thrive on!

Paul

Dear Paul and Members of Paul’s Posse,

Words are completely inadequate to express my heartfelt thanks to everyone for the extraordinary support of our mission here at Dana-Farber Cancer Institute given by all the members of Paul’s Posse through the Pan Mass Challenge.  Since joining together with a shared vision only three years ago, this team has raised more than $1 million for research to advance our understanding of GIST so that we can use this knowledge to develop new targeted therapies to help patients.

At the deepest level, this is a testimony to the warmth and respect that we all feel for Paul, and our research team and I are inspired to work harder every day to make the very best use of these important funds.  In these challenging economic times, we make sure that every dollar for research goes as far as it can towards finding new breakthroughs and offering  patients effective new treatment options as quickly as possible, as if our own lives depend on this (since other lives do depend on this).  We are so happy to tell you that these funds are enabling our team to make some of the most rapid translations of laboratory discoveries into clinical application.  In collaboration with colleagues across the world, our team has been privileged to be at the cutting edge of some of the most innovative new drug development projects in GIST and other cancers. 

We simply could never accomplish all that we do in our research without the “grass roots” support of Paul’s Posse, the PMC, and the generosity of all the individual donors who have made this possible.  The Posse has a remarkable spirit, and that spirit has been transformed into the support that powers our research and care mission here at Dana-Farber, and one in which we are working in collaboration with experts around the world to reduce the burden of GIST and other cancers for patients everywhere.

I hope we can all celebrate together again next year, and I certainly hope to share with everyone more results from our very promising work in this field.

POSSE UP, and thanks again to everyone for keeping the spirit thriving!

George D. Demetri, MD    

Pan-Mass Challenge - MISSION ACCOMPLISHED

Howdy,

 

I just came back from riding in this year's Pan-Mass Challenge. I can happily say, "MISSION ACCOMPLISHED;" I finished.  We were blessed by almost perfect weather--not too hot, no rain and reasonable headwinds on the Cape.  This year, thankfully, we had no broken bones, stitches, or road rash. I am thrilled to report that as of this moment we have collectively raised more than $100,000 and counting as monies are still coming in.

It's been three years now that I pulled together 'Paul's Posse' to support me and my formidable battle with cancer. This year 'The Posse' rode the PMC together again with our bond and determination as strong as ever.  If it was not for my fellow Posse members, I would not have completed my 12th PMC, considering just a short 90+ days ago; I was recovering from major surgery and a very uncertain future. I am so very thankful and each day is an absolute blessing.

This year two scenes particularly struck me.  The first was a child at the third water stop on the first day holding a sign saying "I'm 13 this year because of you."  The second was the 100+ kids at the Cape Cod Sea Camp who scream their heads off in support as we rode passed. The PMC is not about the personal achievement - it's about what we, who are strong and able, can give to others- life and hope.

The PMC is unquestionably a reaffirmation of the human spirit. I cannot help but hope that this collective support, focus, and determination will be rewarded someday soon with cures.

Thank you so very much for your wonderful friendship. 

I Thrive On,

 

Paul

This weekend Paul's Posse Rides again!

Howdy,

Well, it has been a about 3 years since I was diagnosed with Cancer and 2 years since I had my first cancer resection surgery.  Since my last surgery 90 days ago, I have ridden my bike 373 miles (but who's counting?) training for the Pan Mass Challenge ("PMC"), which takes place this coming weekend: 192 miles from Sturbridge, MA to the tip of Cape Cod in Provincetown.  I WILL FINISH though it might not be with the same pizzazz as in years past.

 

For the past 11 years I have ridden in the PMC and now that I am a "Thriving" cancer patient, the 2009 PMC will be more meaningful than ever for me.

 

In the past, I always rode to help raise money for cancer research, but I never imagined I would ride as a possible beneficiary of that research.

 

As for the ride itself, I am again making the trip with a group of friends who are known on the road as "Paul's Posse." All the money we raise will again go directly to support the research of Dr. George  Demetri, the world's leading authority on GIST, the type of cancerous tumor that found its way into my body. I have even convinced George, to ride in the PMC again!

 

I've taken this challenge seriously for these past 11 years, and I can tell you that now, more than ever, I want to be a part of the effort to search for a solution.  Before my diagnosis, cancer was a concept, a bad thing that was happening to other people, and a bad thing that I wanted to help stop. Now that I am a patient, I understand the importance of the PMC on a whole new level. Now, when I talk about hope on the roads of Massachusetts, it is no longer a conversation about the looks on the faces of the thousands upon thousands of supporters lining the route. It is now a conversation about my own future, my own treatment, and the hope that new research will one day leave me cancer free.

 

For my part, I am and have sent out countless letters raising money, trained (wish I had more miles under my belt), and will do the ride - all 192 miles of it - never losing hope.

 

If you are reading my Blog, I'm asking you to make a pledge to the cause.  As in 2008 when the members of Paul's Posse raised nearly $300,000, 100% percent of the monies raised by Paul's Posse this year will go directly to the Dr. George Demetri at the Dana Farber Cancer Institute. 

 

I realize the economic environment is less than optimal for most of us.  That said, I would be so grateful and appreciative if you would consider making a contribution to this event. Every dollar counts, every dollar makes a difference, and every dollar yields ever increasing possibility.

 

I truly believe somewhere along the road between Sturbridge and Provincetown lies a cure for cancer, maybe even for me. You can help us find it.

Thanks for joining the battle.

Thrive On,
Paul

Click here to visit my personal page and make an online donation. 

Paul's Posse 2009 PMC Ride

If the text above does not appear as a clickable link, you can visit the web address:

https://www.pmc.org/egifts/ps0036

Paul's Daily Dose - I'm back!

Howdy,

 

I’m back!  Back home from another round of surgery, no, there was nothing malignant, but there were 7 rapidly growing tumors that my doctors needed to remove.  It feels great to be home, but there were moments over the last 14 days where the pain and discomfort were unbearable.  However, as a cancer Thriver, I have learned to count the victories, not the setbacks and my surgery last week was a victory.  A victory and a blessing that I share with my doctors, nurses and friends, most importantly Gretchen.  It was their strength, support, and love that carried me through and I am most grateful.

 

Thriving is a mindset in which one is careful to avoid regrets and embrace opportunity at every corner.  Yes, I have cancer, and that sucks, but things could be worse:  I could have allowed the illness to keep me away from my love of cycling.  I could have let the disease change me.  Instead, I have, and will continue to do my best, to define what it means to be a cancer Thriver.

 

For the past 11 years I have ridden in the Pan-Mass Challenge, a two-day, 192-mile cycling event that raises money in support of the Jimmy Fund and the Dana-Farber Cancer Institute.  The Pan-Mass Challenge has grown tremendously over time, and the event raised over $35 million last year, bringing their all time total to more than $238 million.

 

As a cancer Thriver, and now two time cancer surgery graduate, the 2009 Pan-Mass Challenge will be more meaningful than ever for me.

So on August 1^st, I will start my 12th Pan Mass challenge with my fellow riders of ‘Paul’s Posse’.  It is going to be harder because of my surgery, new chemotherapy regimen, and lack of training. But I am going to do it. 

 

I’ve taken this challenge seriously for these past 11 years, and I can tell you that now, more than ever, I want to be a part of the effort to search for a solution, and I am hoping that you want to be a part of it too.  Before my diagnosis, cancer was a concept, a bad thing that was happening to other people, a bad thing that I wanted to help stop.  Now, as a patient for the past two years, I understand the importance of the PMC on a whole new level.  Now, when I talk about hope on the roads of Massachusetts, it is no longer a conversation about the looks on the faces of the thousands upon thousands of supporters lining the route.  It is now a conversation about my own future, my own treatment, and the hope that new research will one day leave me cancer free.  For my part, I am asking myself to send out countless letters raising money, train hard and do the ride, and never stop hoping.  For your part, I’m asking you to make a pledge to the cause.

 

You’d be hard-pressed to find a more worthy and leaner organization.  In 2008, 100 percent of all funds raised by PMC riders went directly to the Jimmy Fund.  More importantly, as in 2008, when the members of ‘Paul’s Posse’ raised nearly $300,000, 100% of the money raised by ‘Paul’s Posse’ this year will go directly to support the work of my doctor, friend, and three time ‘Paul’s Posse’ member, Dr. George D. Demetri at Dana-Farber.

 

Your tax-deductible check can be made payable to PMC/Jimmy Fund and you can mail it to me. Alternatively, you can use your credit card to make a donation https://www.pmc.org/egifts/my egift ID is PS0036.  

 

I know these are tough financial times, but cancer doesn’t know we’re in a recession, so please donate what you can.

Gratefully,
Paul

Paul's Daily Dose - 5/4/09

Paul's surgery was more complicated than expected. The surgeon found and removed 9 tumors in 6.5 hours as compared to the original plan of removing the identified 3 tumors in 2.5 hrs.  Essentially, the “Chip Shot” turned into a “Par 5.” He weathered the surgery well and now faces the challenges of recovery. 

The good news is that the final pathology report confirmed what the doctor’s thought – all 9 were Desmoid tumors.  The plan of attack going forward seems to be a doubling of his current Gleevec dose!!!  Great news all things considered.

 

Paul’s recovery has been somewhat typical for such an extensive surgical procedure.  The first two days, Paul was feeling pretty good doing his laps around the hospital floor and having visitors.  These last few days have been more difficult and the level of discomfort significantly heightened.  The doctors assured us that his recovery is following the expected path.  Paul, too, recalls a similar cycle the last time around.  We anticipate his energy level to strengthen and his physical activities to increase.  With some luck, he might well be able to go home by weeks end. 

Thank you so much for your love and support. 

 

 

As Paul would say: Thrive on!!!

Thank you!

Gretchen

 

Paul's Daily Dose - surgery is over!

Paul's surgery was more complicated than expected. The tumors are likely desmoid as originally thought, but we are awaiting pathology which could take as much as 5 days (hopefully sooner.)

 

He weathered the surgery well and may be up and possibly walking before the day’s end.  As Paul has mentioned to more than a few of us - 64 laps around the hospital floor equals 1 mile. 

 

Paul is so thankful for all the love and support from all of you.  He feels very luck and blessed.

 

I will keep you posted. 

 

As Paul would say:

 

Thirive on!!!

 

Thank you!

 

Gretchen

Paul's Daily Dose - Medical update

OK, not so good news.

I don’t know if you are jonesing for the TV show “ER” or you find that “House” just doesn’t cut it (no pun intended). Well, here’s a new one “Paul goes back to the OR.”

All kidding aside, I am headed back to the OR.

Here is the scoop...
 
I had tests last week and my desmoid tumors continue to grow and need to be removed.  My doctors not wanting to waste any time, have scheduled me for surgery April 28th.  The procedure, which I hope will be followed by a speedy recovery, will not be as involved as my initial surgery.  To quote one of my doctors, this surgery is a "chip shot" (I am hoping he is a good golfer!).    
 
As I have said so many times before, I have wonderful doctors in whom I am totally confident. 
 
Thank you for your support and I Thrive on,
 
Paul

Paul's Daily Dose - Medical update

Good news!

 

As you know from my previous post, my tests came back positive for tumor growth.  Since then, I have had additional tests, I have received the definitive results.  Defying the odds, these new tumors are NOT a recurrence of GIST!  I have another growth; they're called fibromatosis or desmoid tumors. 

 

 

Desmoid tumors are somewhere in between truly benign tumors and the malignant tumors. Desmoids are not truly benign because they are locally aggressive, but they do not metastasize like malignant cancers. Long story short – Desmoids don’t grow like metastatic cancers but can cause associated problems due to their size and location.  As mine are inoperable, they are just going to monitor.

 

To quote Gary Schwartz, one of my amazing doctors:  "Paul, you dodged a bullet."  Needless to say I am very fortunate.  Thanks to everyone for your support. 

 

Thrive on,

Paul

Paul's Daily Dose - Medical update

Howdy,

 

To steal a line from Elton John, “The Bitch is Back!”

Yes, I am very sorry to report that my cancer has once again has shown its’ ugly face. 

A week ago, I had a PT/CT scan and got the disturbing news: “We saw something we don’t like”. 

 It’s a refrain you never get used to.   

The scans showed multiple growths in the abdomen that were not present 3 months ago. Subsequent tests confirm that my cancer has mutated and is now resistant to my current drug therapy.  As I have said so many times before, I have the BEST team of doctors and I am confident they will come up with a new “cancer cocktail”, as surgery is not an option. I know that they are going to do everything possible and you know that I will fight with everything I have.  I did not pick this fight with cancer, but it’s a battle I will win.

As a cancer Thriver, I have learned to count the victories, not the setbacks.  Last year, I finished the NYC marathon for the second time, and the PMC for the 11th.  This year, I hope to complete my 12th PMC, but may need to compete in a different sort of marathon between now and then.

 As always, I will draw more strength than you can imagine from the support my friends my original diagnosis, and for that I remain eternally grateful.

 Thriving is a mindset in which one is careful to avoid regrets and embrace opportunity at every corner.  Yes, cancer is back, and that sucks, but things could be worse:  I could have allowed the illness to keep me away from the marathons, the triathlons and the PMC.  I could have let the disease change me.  Instead, I have, and will continue to do my best, to define what it means to be a cancer Thriver.

I Thirve on,

Paul

Paul's Posse rode again - and raised over $67k

Thank you!

Cycle for Survival was a huge success exceeding the fund-raising goal of $1.2 million.  Thanks to you – Paul’s Posse collectively raised over $67,000 of that total.

Profound and inspirational – such a large group of people with varying backgrounds spinning together for some part of eight hours in complete solidarity with a singular goal and wish - to combat cancer (orphaned cancers, more specifically).

I am pleased and honored that two of my doctors from Memorial Sloan Kettering (“MSK”) not only showed up but actively participated, breaking a sweat in both cases!  It was remarkable how many thankful patients, family members, and friends approached them and recalled their ‘story’ – a story encompassing great care, hope, and the best science & research focused on curing cancer.  As a MSK cancer THRIVER, the event was overwhelmingly emotional and simultaneously energizing.  

So, thank you so very much for your generous contribution.  As I said in my solicitation, every dollar counts, every dollar makes a difference, and every dollar yields ever increasing possibility.  

Thrive on,

Paul.  

Paul's Posse rides again! (sort of)

Howdy,

 

On Sunday, January 25th I will be participating in 'Cycle for Survival', an indoor cycling event benefiting lifesaving cancer research at Memorial Sloan-Kettering (MSK).  I am joined by others and especially my dear friend and doctor at MSK, Gary Schwartz.  I think the following letter Gary wrote is very compelling as to why we need your support.

To my patients and their families:

If you are reading this letter it is either because I have taken care of either you or one of your family members at Memorial Sloan-Kettering Cancer Center in New York.  I am writing to you now to ask for your help.   This year we are facing huge cut-backs in federal funding for cancer research.   As Chief of the Melanoma/Sarcoma Service and as Director of the Laboratory for New Drug Development, I have led a major effort to find new treatments for patients with cancer.   This includes patients with cancers of the skin, soft tissue, as well as cancers of the gastrointestinal tract.    Based on these laboratory efforts we have launched many new clinical programs at MSKCC.   Some of you may have benefited from them.   The future success of this cancer research program will depend on continued research funding.  

In order to raise cancer awareness and to raise the money we need to sustain our cancer research efforts, on Sunday January 25, 2009 I will be participating in an indoor cycling event called "Cycle for Survival".  I will be part of cycling relay team to benefit MSKCC. This event will be held at Equinox health clubs throughout New York.   Two hundred bicycling teams will be pedaling their hearts out to raise money for cancer research. This year it has been determined that a large share of this money will go directly to my laboratory and clinical research program. 

One of my patient's, Paul Schaye, will be the captain of my relay team.  Paul is an amazing person.   He is a patient with a gastrointestinal stromal tumor (GIST) who is on the drug called Gleevec.  This last year he underwent major surgery to remove this cancer from his stomach as well as from his liver.  Today he is cancer free.   What is truly remarkable about Paul is that he just completed the New York City marathon! 

On January 25th, Paul and I will be biking for you and our MSKCC family.  I am closing in on my 19th year at MSKCC.  Never once have I written a letter like this and never once did I ever envision that I would have to do so.    But, desperate times require desperate measures.

Thank you in advance for supporting our efforts in our fight against cancer,

Sincerely,

Gary K. Schwartz, MD

 

The following link is a clip of Gary discussing his research and the Spin event.

Fox News - Cycle for Survival

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http://www.myfoxny.com/myfox/pages/InsideFox/Detail?contentId=8295607&version=1&locale=EN-US&layoutCode=VSTY&pageId=5.2.1

 

I know the holidays are just days behind us, and I realize the economic environment is less than optimal for most of us.  That said, I would be so grateful and appreciative if you would consider making a contribution to this event. Every dollar counts, every dollar makes a difference, and every dollar yields ever increasing possibility.  

To make a donation please Click here
If the text above does not appear as a clickable link, you can visit the web address:

http://mskcc.convio.net/site/TR/CycleforSurvival/AG_Cycle_Event?pg=personal&fr_id=1050&fr_id=1050&px=1156161

 

Click here to view the team page for Paul's Posse

If the text above does not appear as a clickable link, you can visit the web address:

http://mskcc.convio.net/site/TR/CycleforSurvival/AG_Cycle_Event?pg=team&fr_id=1050&team_id=4120

 

Thank you so much for your support. 

Thrive on,
Paul

 

 

MISSION ACCOMPLISHED!!!

I did it; I made it to the finish line of the New York City Marathon!

The single most overwhelming feeling that I felt coming over the line was gratitude and yes, relief. Hey, 26.2 miles is a long way!

I could not have done it without the support of my dear friends and more importantly my ‘running’ Posse of Fran, Jim and Liz. They accompanied and cajoled me to the finish line. Their encouragement, threats, jokes, and love, got me through the race.

Your support on this journey is very much appreciated. I am amazed how many of you continue to read all of my emails/posts, and I am very grateful. I cannot put into words how your friendship has touched me. Thank you so very much.

Thrive on,

Paul

Here is more: Schaye – New York Post November 2, 2008